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Based on observations from bariatric surgery literature, rapid loss of adipose tissue alters body mechanics, weight distribution, and postural alignment

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Treatment in combination with a sulfonylurea or insulin may have an increased risk of hypoglycaemia

A comprehensive metabolic evaluation helps distinguish whether combined therapy addresses a genuine biomarker-driven need or represents empirical experimentation

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These shifts are driven by the GLP-1 receptor activation in brain regions that process food reward, and they tend to intensify as the dose increases