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Additionally, while FOXO4-DRI has been shown to limit chemotoxicity in certain contexts, its overall safety profile in humans requires further research to fully understand all potential side effects

It is an important donor of the 1-carbon methyl-group essential for multiple cellular reactions, including purines for deoxyribonucleic acid (DNA) synthesis

Neurology 57(5):933

Zepbound has not been studied in patients with a history of pancreatitis, or with severe gastrointestinal disease, including severe gastroparesis, and it is unknown if patients with a history of pancreatitis are at higher risk for developing pancreatitis on Zepbound

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Old gynecomastia, where tissue has become fibrotic, is not going to respond significantly to drugs alone and may still require excision