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A 12-week randomized controlled trial in vegans and vegetarians with marginal deficiency (Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status, Del Bo and colleagues, Clinical Nutrition , 2018, 40 subjects) found that even a modest sublingual dose of about 50 mcg per day restored serum B12 and improved holotranscobalamin, methylmalonic acid, and homocysteine, which confirms that sublingual liquid B12 can correct a marginal deficiency in plant-based eaters