2016 Jul;12(Suppl 4):S389-S394
It works by influencing the balance of neurotransmitters in the brain, specifically serotonin, which plays a key role in mood regulation
When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion The pancreas releases insulin in response to elevated blood glucose levels, but only when needed (glucose-dependent mechanism) Reduced glucagon release Glucagon, which raises blood sugar, is suppressed when glucose levels are adequate Delayed gastric emptying Food moves more slowly from the stomach into the intestines, promoting satiety Appetite regulation Signals to the brain's appetite centres reduce hunger and food intake Unlike naturally occurring GLP-1, which is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes, pharmaceutical GLP-1 receptor agonists are chemically modified to resist this degradation
Common side effects can include injection-site reactions, itching, rash, weight gain, and swelling
doi:10.1038/s41366-024-01529-z
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