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Patients should be advised that NHS-funded treatment duration is typically limited to a maximum of 2 years, as per NICE guidance, and that discontinuation often results in weight regain

When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives

This study showed that in some people, autoantibodies are blocking CD320 from getting B12 into the cerebrospinal fluid to carry it to the brain