Most GLP-1RAs, aside from a new oral formulation of semaglutide (Rybelsus tablets), are administered subcutaneously via pen-like devices (once daily to once weekly) due to poor oral bioavailability, and all are renally excreted 1
GLP-1 Overview GLP-1 is a peptide composed of 3637 amino acids, derived from the cleavage of proglucagon encoded by the Gcg gene [5]
Remember, everyones experience with GLP-1 medications is different, so its important to listen to your body and make adjustments as needed
Nonetheless, certain obese individuals at very high risk of T2D, atherosclerotic cardiovascular disease, heart failure, or renal failure could benefit from such a monotherapy
The fix: weigh yourself once per week under consistent conditions
I've had type 1 diabetes since I was 10, and since my diagnosis, I've dealt with insulin resistance