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In addition, Fe 2+ is a cofactor of lipoxygenases (LOXs) that catalyzes PUFA-containing phospholipids into pro-ferroptotic lipid peroxidation (Yang et al., 2016)

XL413, a cell division cycle 7 kinase inhibitor enhanced the anti-fibrotic effect of pirfenidone on TGF-beta1-stimulated C3H10T1/2 cells via Smad2/4

Several plants like Arisaema amurense , Biota orientalis , Mentha arvensis , Salvia miltiorrhiza , Albizia julibrissin , Astragalus membranaceus , Glycyrrhiza uralensis have been found to have an inhibitory effect on mono-amine oxidase-B (MAO-B)enzyme activity [21]

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