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Environmental insults such as airborne pollutants, cigarette smoke, and occupational exposures (e.g., asbestos, silica) are well-documented oxidative stress in the lung

Chronic hyperinsulinemia promotes human hepatocyte senescence

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The expression of the VD metabolism genes CYP2R1 and CYP27A1 (25-hydroxylase), CYP27B1 (1--hydroxylase), and vitamin D receptor (VDR) were downregulated in the livers of mice fed an HFD (GSH- deficient) compared with control diet-fed group

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