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Notch signaling In the process of aging, the Notch signaling pathway is activated or inhibited in different tissues due to ligand-receptor imbalance, -Secretase abnormalities and downstream transcription disorders, which drive neurodegenerative diseases, cardiovascular diseases, immune senescence and metabolic disorders

Includes alpha lipoic acid, a compound that plays a role in energy metabolism

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doi:10.1016/j.neuroscience.2007.10.041 Epstein, J., Sanderson, I., & MacDonald, T