While the compounds structure is undisclosed, it is described to have potent activity on hMC4R in a functional cAMP assay (EC 50 = 2 nM, E max = 95%), inactivity on hMC3R, and reduced potency on hMC1R (25, 136)
Some common side effects include: Mild Effects: Temporary fatigue, nausea, or water retention
Reduces inflammation: Glutathione has anti-inflammatory properties that may help to reduce inflammation throughout the body
CI: Confidence Intervals
This mechanism has been validated in RCTs in populations including older adults, hemodialysis patients, and schizophrenia patients on maintenance medication
It can be highly activated by various stress stimuli, where it is required for the re-folding of damaged and unfolded proteins generated under stress 43