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Given that infusions of GLP-1(2836) and GLP-1 have been shown to influence body weight and blood glucose levels in high-fat dietfed mice (24) and that we ourselves have documented an effect of calorie restriction and weight loss on cardioprotection (25), we examined the consequence of our 14-day infusions on these parameters

Semaglutide, with its 7-day half-life, maintains therapeutic plasma concentrations continuously, producing consistent 24-hour receptor activation and clinically meaningful metabolic improvements

CRP (C-reactive protein) serves as the most commonly measured marker of systemic inflammation

Treatment with the combination drug also delayed the need for insulin therapy

doi: 10.1038/nrendo.2012.140 29 Russell-JonesD

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