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The administration of cagrilintide, an extended-release amylin analog, in combination with semaglutide has shown average weight loss of 22.7% after 68 weeks of treatment in obese subjects compared to 15.7% weight loss with semaglutide alone, marking a 44% increase in weight loss efficacy compared to monotherapy, and putting it into a category of bariatric surgery alternatives

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N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor