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In certain embodiments of the present disclosure, the amount of buffer included in the gel formulations are an amount such that the pH of the gel formulation does not interfere with the auris media or auris interna's natural buffering system, or does not interfere with the natural pH of the endolymph or perilymph, depending on where in the cochlea the otic formulation is targeted

In light of current evidence, it seems unlikely that methotrexate alone is capable of inducing chronic liver disease

Neurology 2013;80:1762-70

This injectable form is designed for precise protocol exploration where targeted delivery and accurate dosing matter

The second loop of occludin is required for suppression of Raf1-induced tumor growth

Stria of all ages can then be grown under similar treatment conditions as for SGNs and cochleae as described above for the evaluation of otoprotectant agents