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The delay between glutathiones discovery in 1888 and its clinical use in the 1980s stems from three factors: poor oral bioavailability (the tripeptide was degraded in the gut before absorption), lack of understanding of its antioxidant mechanism until glutathione peroxidase was discovered in 1957, and institutional medicines slow adoption of redox biology as a treatment framework

Furthermore, these molecules also have extrapancreatic mechanisms of action that contribute to their glucose lowering properties, such as slow gastric emptying and increase satiety (Figure 1)

A narrative review of the pathogenesis

Recommended Dosage: For optimal results, the recommended dosage is one capsule one to two times per day, preferably on an empty stomach or as directed by a healthcare professional

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