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In comparison, SLIT offers a safer option with fewer side effects, though it is generally less effective [92, 93]

It is the regulatory baseline for 503A compounding facilities operating under FDA oversight

In the KEYNOTE-119 trial, monotherapeutic pembrolizumab did not significantly improve OS in patients with previously treated metastatic TNBC compared to chemotherapy, which might inform future research of pembrolizumab monotherapy for selected patients, specifically those with PD-L1-enriched tumors, and combinatorial approach might be necessary for the treatment of patients with metastatic TNBC

doi: 10.1186/s13075-018-1537-8 145 BoehmeMWGaoIKNordenCLemmelEM

Exposure is brief, self-limited, and cleared within the hour