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doi: 10.3390/polym13071027

Cumulative ultraviolet radiation exposure significantly contributes to reduced skin elasticity and can exacerbate the appearance of skin laxity during weight loss

10.1038/nrm.2016.140 241 Saint-GermainE.MignaccaL.VernierM.BobbalaD.IlangumaranS.FerbeyreG

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This transcriptionally active complex promotes the expression of a range of pro-fibrotic genes including Snail, MMP-7, Twist1, fibronectin 1, -SMA, CTGF, collagen 1 A, and PAI-1 [30, 31] (Fig