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Helicobacter GGT has been shown to inhibit proliferation of T-lymphocytes, an effect that has been suggested to play a role in the immune escape by these bacteria 16,49

78,399 AZD3965 has already finished a Phase I/II clinical trial (NCT01791595) in patients with solid tumors diffuse large B-cell lymphoma, 76,79 which reveals its pharmacokinetic characteristics and adverse effects and suggests that AZD3965 is tolerated at doses that produce target engagement

These approaches could maximize the benefits of dual agonism while personalizing treatment to individual patient needs

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K., Tognon, C