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Both require specific administration instructions (take on empty stomach, wait 30 minutes before eating) to ensure absorption

Fat loss is the main contributor

Emerging data mostly acquired from the CVOTs conducted for the various GLP-1 receptor agonists now available, also suggest that they may offer renoprotection [8]

The FDA last week issued warning letters against a handful of companies flagging violations regarding the promotion and sale of unapproved weight-loss drugs, including unlicensed versions of the blockbuster therapies semaglutide and tirzepatide

Reference List Cleveland Clinic

The choice between them may ultimately depend on clinical indication: retatrutide for maximum weight loss and metabolic improvement, survodutide for MASH-focused treatment where it has the most advanced regulatory pathway