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It was shown that L-theanine (600 g/mL) could induce apoptosis of tumor cells through the mitochondrial pathway in human HepG2 hepatoblastoma cells and HeLa adenocarcinoma cells (71)

Phosphorylated Smad2/3 complexes then translocate to the nucleus, where they induce transcription of fibrogenic genes, including collagen I/III, fibronectin, and -smooth muscle actin (-SMA)

The shape of mitochondria changes from a long rod shape to a punctate shape along with a ruptured outer membrane [20,21,22]

In particular, erythrocyte structure (visible structural membrane changes and eryptosis initiation) was notably affected by IL-8 [269]

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