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So far, animal studies report no toxicity or major side effects , even at higher doses

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A meta-analysis of four observational studies, following a total of 7,475 older individuals for 3 to 16 years, found a weak association between an elevation in vitamin B 12 of 50 pmol/L in blood and a reduction in fracture risk (114)

& Fenton, K

Left untreated, constipation can lead to more severe and potentially fatal conditions like ileus