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Moreover, the 4050% non-response rate to current biologics underscores the influence of the complex genetic profiles on the clinical outcomes

Important differences from humans include the disproportionately large cecum, coprophagic behavior, standardized laboratory diets, and specific-pathogen-free housing conditions, all of which can substantially influence microbial composition and metabolic interactions

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JAMA Surg 158(10):10031011 Miras AD et al (2019) Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial