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It may mean the onboarding process failed, the dose was too aggressive, the patient never got a clear protocol, or the support system around the medication was too thin

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Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial

Nature , 378, 776-779

Growth and puberty in a 2-year open-label study of lisdexamfetamine dimesylate in children and adolescents with attention-deficit/hyperactivity disorder

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