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Effect of Volume and Timing of Water Consumption: Single oral doses of semaglutide tablets were administered with 50 mL or 240 mL of water after an 8-hour overnight fast and a continued fast of 4 hours post-dose in healthy subjects

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McGuire DK, Shih WJ, Cosentino F, Charbonnel B, Cherney DZ, Dagogo-Jack S, et al

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Conversely, several clinical trials have shown that dipeptidyl peptidase 4 (DPP-4) inhibitors, another type of oral incretin-based therapy, have a neutral effect on CVD in patients with T2DM [9,10,11]