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BMC Med 14(1):83 Zevin AS et al (2016) Microbial translocation and microbiome dysbiosis in HIV-associated immune activation

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Specifically, exenatide treatment over 48 to 60 weeks increased tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) in neuronal-derived extracellular vesicles (exosomes), alongside activation of downstream signaling proteins such as total Akt and phosphorylated mTOR [61]