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Starting in 2008, large cardiovascular outcome trials (CVOTs) have been carried out to test the safety and efficacy of new glucose-lowering agents, revealing the cardiovascular protective actions of glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs)

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An initial approach to the quantification of total tissue polysulfides was to use a phosphine that incorporates the sulfane sulfur atom into a diagnostic derivative, in conjunction with isotope dilution and liquid chromatography tandem mass spectrometry (LC-MS/MS) 31,32