1 Introduction The global prevalence of non-alcoholic fatty liver disease (NAFLD) has shown a consistent upward trend in recent decades, with current estimates indicating an overall prevalence of 30.05% ( In a pivotal 2023 consensus statement, international liver associations proposed redefining disease terminology, replacing NAFLD with metabolic dysfunction-associated steatotic liver disease (MASLD) and NASH with metabolic dysfunction-associated steatohepatitis (MASH) ( MASLD pathogenesis involves complex interactions among multiple pathological processes, including excessive fatty acid accumulation, dysregulated inflammatory responses, oxidative stress, and insulin resistance
They promote weight loss by increasing insulin sensitivity, slowing gastric emptying, and reducing appetite
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Simultaneously, this decreasing pool of alive cells keeps secreting glutathione until, after ~300 h, the probability of replicating is very close to the probability of dying and very few alive cells are left in the population
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