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About 90% peripheral serotonin is synthesized in enterochromaffin (EC) cells [61] and regulated by rate-limiting enzyme called tryptophan hydroxylase (Tph) [62]

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J Head Trauma Rehabil 27(6):E1-14 Ali F et al (2023) Chronic refractory insomnia in a patient with undiagnosed bipolar disorder and long-standing traumatic brain injury

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These results were further supported by another study from the same lab, whereby GLP-1 was shown to stimulate myocardial glucose uptake via mechanisms that were p38 MAP kinase and NO dependent, but independent of adenylyl cyclase or Akt [73]