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As Morgan Stewart, PharmD from the University of Texas at Austin, notes: "Tirzepatide sometimes causes more side effects than semaglutide because it works on two hormones instead of one." Additionally, Tirzepatide has yet to receive FDA approval for cardiovascular benefits, which are still under study

If you look hard enough, you might find weak GWAS signals near GLP1R for BMI or related traits, but none are convincing

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A healthy rate of weight loss on GLP-1s is about one to two pounds per week, with many people reaching five to ten percent of their starting body weight lost over three to six months

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