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Its meant to be an exception to the normal drug supply chain, helping patients who cannot take a drug in its existing form or filling in when there are shortages of a life-saving medication

A prominent example is the calcineurin inhibitor cyclosporine coadministration of berberine has been shown to markedly increase cyclosporine blood concentrations, risking toxicity

2004 Sep;97(9):887-9

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Many patients find that pairing it with lifestyle changes such as a balanced diet, regular exercise, and behavioral adjustments can further enhance weight loss