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In addition, macrophages secrete sphingomyelinase, which has been reported to act synergistically with LPL to promote binding of LDL and lipoprotein (a) (Lp(a)) to vascular smooth muscle cells (VSMC) and the extracellular matrix promoting their retention in the artery (239,240)

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In conclusion, PNC-27 presents an exciting avenue for cancer research, offering a novel and targeted approach to cancer treatment

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Our current findings in aging or HFD-fed mice with abrogation of improved lipid tolerance, despite reduced DPP-4 activity and increased GLP-1 levels, suggest that the concept of GLP-1 resistance should be further explored in studies examining the GLP-1dependent control of TG excursion

Identified publications were reviewed for relevant data and were included in the review if appropriate