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In addition, epidemiological studies have demonstrated that patients with Type 2 diabetes who used GLP-1 RAs were less likely to be diagnosed with nicotine misuse compared to those who used other medicines for Type 2 diabetes

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PMID 38885378

At any rate, the long-term role of NCC either as an ion transporter sensitive to thiazides, as an IL-18 receptor or as a potential partner for GLP-1 receptors in -cells or in any capacity in metabolically active tissue awaits exploration, particularly within the context of obesity, the most prevalent component of MetS