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Lancet Diabetes Endocrinol 7(7):549559 Mok J et al (2023) Safety and efficacy of liraglutide, 3.0 mg, once daily vs placebo in patients with poor weight loss following metabolic surgery: the BARI-OPTIMISE randomized clinical trial

doi: 10.1038/s41586-019-1785-z 97 SongXSunXOhSFWuMZhangYZhengWet al

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The goal is to follow children over years or decades to create evidence about long-term effects

However, the lack of significant statistical interaction between subgroups (P = 0.127) suggests that addition of the AMPLITUDE-O trial has not changed the previous scenario [5], stressing that the net separation on MACE effect between patients with or without established CV disease may be more nuanced than suggested by previous meta-analyses [3]

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