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Both dosage regimens showed significant benefits in PN symptoms compared with baseline with no significant difference between the groups

This can significantly reduce blood pooling in the legs, improve oxygen delivery to the brain, and lessen the compensatory adrenaline surges that cause tachycardia and heart palpitations

Seek medical advice if you experience: New-onset insomnia or significant sleep disruption that persists after starting B12 supplementation Paradoxical fatigue : Worsening tiredness despite taking B12, which may indicate an underlying condition requiring investigation Neurological symptoms : Tingling, numbness, balance problems, or cognitive changes, which could suggest B12 deficiency or other neurological conditions Mood changes : Anxiety, agitation, or depression that develops or worsens after starting supplementation Palpitations or rapid heartbeat : Though rare, some individuals report cardiovascular symptoms that should be evaluated It's important to note that sleep disturbances may be unrelated to B12 supplementation

bioRxiv2025 Aug 31