Like cisplatin, it contains two chloride ligands, which are released within the cellular environment and interact with DNA to form intra- and interstrand cross-links.3 These DNA adducts trigger multiple cellular responses, including DNA damage recognition and repair, cell cycle arrest, and activation of apoptotic signaling pathways, ultimately inhibiting cell proliferation.4 Ovarian cancer remains one of the leading causes of mortality among gynecological malignancies, with epithelial ovarian carcinoma accounting for more than 90% of all cases.5 The current standard therapy involves primary cytoreductive surgery followed by platinum-based combination chemotherapy administered as soon as possible after surgery.6 However, a major limitation of these treatments is the dose-dependent toxicity associated with platinum compounds, which can result in significant off-target tissue injury.7 It is well established that Reactive Oxygen Species (ROS) generated during the metabolism of platinum-based agents contribute to this toxicity, particularly in the reproductive system
If your insurance company denies coverage for GLP-1 medications, you have the right to appeal the decision
In fact, the presence of dyslipidaemia alongside obesity may strengthen the clinical indication for these treatments, as both conditions contribute to cardiovascular risk
Importance of Early Diagnosis Early diagnosis and hyperthyroidism treatment are crucial to prevent complications such as heart problems, bone loss, and thyrotoxic crisis
doi: 10.1093/toxsci/kfp052
Efficacy and safety of canagliflozin in subjects with type 2 diabetes: systematic review and meta-analysis
