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Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure
130-132 Many people who reduce their weight on GLP-1s experience improved mood, including fewer depressive symptoms
10.1016/j.biopha.2019.01.034 Summary Keywords GLP-1, GLP-1 analog, diabetic retinopathy, mitophagy, retinal ganglion cell Citation Zhou H, Ma X, Lin W, Hao M, Yu X, Li H, Xu C and Kuang H (2021) Neuroprotective Role of GLP-1 Analog for Retinal Ganglion Cells via PINK1/Parkin-Mediated Mitophagy in Diabetic Retinopathy
As a result of the extra weight, she was experiencing strain on her joints every time she ran down a ball
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