Melasma
doi: 10.1093/jn/125.2.293 113 YetginSHincalFBaaranNCilivG
Mayo Clinic reports that strength training can help preserve and enhance muscle mass, develop strong bones, manage chronic conditions, sharpen your thinking skills, and improve the ability to perform everyday activities. It also notes that two or three strength training sessions per week can lead to measurable improvements in strength. American Council on Exercise explains that compound exercises involve more muscle tissue, require more oxygen, and increase energy expenditure
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
doi: 10.1016/j.celrep.2021.109235
Key secondary measuresALSFRS-R, respiratory function, and quality-of-lifealso showed no significant benefit at the primary dose.(Calico, Neurology live, Fierce Biotech) Safety profile: Well-tolerated, with similar rates of treatment-emergent adverse events compared to placebo.(Medthority) Exploratory signals: At a higher exploratory dose, investigators noted some positive trends in muscle strength and possibly respiratory function, prompting calls for further exploration.(Neurology live, Fierce Biotech) Status of Other Indications (VWM, MDD, ALS, etc.) Active pipeline entries: AbbVies public pipeline listings still show fosigotifator (ABBV-CLS-7262) as being actively investigated for ALS, Vanishing White Matter (VWM) disease, and Major Depressive Disorder (MDD)
