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The kidney's filtration workload from oral glutathione supplementation is comparable to its workload from any other amino-acid-containing meal nowhere close to the physiological stress of processing high concentrations of intact glutathione delivered directly into systemic circulation via an IV line

Two of the six went to glucagon-like peptide-1 (GLP-1) drugs: Novo Nordisks Wegovy, an injectable form of semaglutide, and Eli Lillys orforglipron, a novel oral non-peptide small molecule

N-Acetyl L-Cysteine (NAC): In a group of hemodialysis patients, NAC resulted in significant reductions in some serum markers of inflammation, possibly through an enhancement of renal glutathione

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The choice should be based on metabolic needs, tolerability, and individual clinical factors

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