GLP-1 receptor agonists are generally well-tolerated, but clinicians and patients must understand their adverse effect profile, particularly when considering use in individuals with eating disorders who may have unique vulnerabilities
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& Millis, K
Using the Broad Institutes Connectivity Map dataset, Pickart and colleagues reported that GHK significantly changed the expression of a very large number of human genes (on the order of thousands when a modest expression-change threshold is applied), up-regulating many and down-regulating others in a pattern the authors interpret as a shift toward a healthier, more repair-competent state
These critical mechanisms behind copper-related cell death underscore the importance of this model for developing molecular targets for future therapeutic strategies aimed at halting WD progression at its core
