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Melatonin treatment also reduced the expression of the apoptotic proteins acetylated forkhead box protein O1 (Ac-Fox01), acetylated p53 (Ac-p53), acetylated nuclear factor kappa-light-chain-enhancer of activated B cells (Ac-NF-kB), and B-cell lymphoma 2 (BCL2)-associated X protein (BAX), while increasing the expression of the antiapoptotic protein B-cell lymphoma 2 (BCL-2) [22 ]

M., Soydaner-Azeloglu, R

Accessed 13 Oct 2017

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For example, KMO deficiency in male mice elevates KYNA and induces depressive-like behaviours via 7nAChR antagonism, impairing cholinergic modulation of prefrontal circuits, effects that are reversed by restoring 7nAChR signalling [71]

No, B12 supplements don't interfere with Ozempic's effectiveness