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In a 4-week controlled trial of VYVANSE in pediatric patients ages 13 to 17 years, mean weight loss from baseline to endpoint was -2.7, -4.3, and -4.8 lbs., respectively, for patients receiving 30 mg, 50 mg, and 70 mg of VYVANSE, compared to a 2.0 pound weight gain for patients receiving placebo
This synergy may also explain the tolerability advantage Tirzepatide demonstrates
Semin Fetal Neonatal Med
A potential mechanism is via GLP-1, which alters gastrointestinal transit, gastric accommodation (63), and has direct effects on hypothalamic nuclei outside of the bloodbrain barrier (64)
The receptor for GLP-1 is the GLP-1 receptor (GLP1R gene, below in the genotype report section), a G-protein-coupled receptor
250 (4): p
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