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Pre-mixed vials raise additional concerns beyond single-compound products: copper-mediated degradation during storage, unknown stability of the four-compound combination, and difficulty verifying each compound is present at labeled concentration

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Current pharmacological treatment options are limited and often underused in clinical practice

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In particular, compared to the mild degeneration group, the expression levels of ferroptosis driver genes ( ACSL4 , SLC39A14 , and CHAC1 ) were relatively higher in the severe degeneration group, whereas the expression levels of ferroptosis suppressor genes ( GPX4 , FTH1 , and HSPB1 ) were significantly lower (Fig