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but extreme conditions, such as strong heating, usually cause irreversible change

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They also significantly reduce phosphorylation of the ryanodine receptor (RyR) at the S2814 site and lower the risk of triggered activity and atrial arrhythmias by suppressing calcium leakage (153), thereby reflecting their antiarrhythmic properties

doi: 10.2337/dc09-1203 55 Elkind-HirschKMarrioneauxOBhushanMVernorDBhushanR