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It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically

Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism

It's likely due to side effects from reduced gastric emptying

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Because it stays latched onto albumin and circulates for days on end, it provides constant, low-level stimulation to the pituitary

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