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Safety, Side Effects, and Clinical Monitoring GLP-1 medications are well-tolerated in most patients, with the most common side effects being nausea, constipation, and reduced appetiteeffects that typically fade as your body adjusts over 48 weeks

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Footnotes Competing Interest Statement: The authors declare no competing interests.

[24] [25] For carefully selected patients with obesity and inadequate response to medical management, bariatric surgery remains the most effective intervention for sustained weight loss and metabolic improvement

FYI, Rybelsus also contains semaglutide and is FDA-approved for type 2 diabetes