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Why Fatigue Can Happen on Tirzepatide or Other GLP-1 Medications Several physical mechanisms can cause tiredness during treatment
What you might notice: mild appetite reduction, occasional nausea after meals, subtle changes in food preferences
Symptoms include shakiness, sweating, confusion, and irritability, which can be difficult to distinguish from severe sleep deprivation
Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, et al
Additionally, GLP-1 receptor agonists act on the brain's appetite centres, particularly in the hypothalamus, to reduce hunger signals and increase satiety