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As GLP-1RAs appear to exert their cardiovascular benefit by mechanisms different from those of both pioglitazone and SGLT2 inhibitors, there would also seem to be a place for a randomised controlled trial comparing a GLP-1RA plus pioglitazone or a GLP-1RA plus SGLT2 inhibitor compared to each monotherapy alone to establish the extent to which extra benefit is accrued with dual or even triple therapy

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