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The answer is citrulline has a longer half-life, meaning it circulates for longer once in our system, and is more effective at increasing levels of arginine than arginine supplements themselves

First, they suggest that AOD-9604 can be used for extended periods without loss of efficacy due to antibody neutralization

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The enhanced helical structure increases receptor affinity by reducing the entropic cost of adopting the bioactive conformation, while the D-amino acid protects against DPP-IV cleavage that normally represents a major degradation pathway

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