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However, this study may have an inherent operational bias as the vibrator was hand-held (allowing possible variation in the pressure applied) and the stimuli were presented in a non-random order 27

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It is a vasodilator, probably related to histamine release in the cells and to prostaglandin inhibition

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Fedorenko, I.V., Gibney, G.T., and Smalley, K.S., NRAS mutant melanoma: biological behavior and future strategies for therapeutic management