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For some this is a matter of vanity, but for the estimated one billion people suffering from obesity in the world, it could prevent serious ill-heath and death

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Additional information Peer review information Nature Communications thanks Neil McDonald, Felix Weis, and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Non-approved alternatives like sublingual drops, patches, or compounded blends with B12 may seem attractive but come with safety uncertainties

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