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GI-sensitive individuals benefit from extended 16-20 week titrations and may find optimal results at maintenance doses of 1.8-2.0mg weekly rather than pushing to 2.4mg

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An updated systematic review and network meta-analysis of GLP-1 receptor agonists and polyagonists ranked retatrutide at or near the top for weight loss among the modern agents, while also flagging that the strongest-effect agents tend to carry the highest adverse-event burden